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Issue 5, 2016
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Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

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Abstract

During efforts to prepare the known compound NMDI1, a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.

Graphical abstract: Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

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Publication details

The article was received on 04 Dec 2015, accepted on 24 Dec 2015 and first published on 24 Dec 2015


Article type: Communication
DOI: 10.1039/C5OB02482J
Citation: Org. Biomol. Chem., 2016,14, 1559-1563
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    Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

    V. J. B. Gotham, M. C. Hobbs, R. Burgin, D. Turton, C. Smythe and I. Coldham, Org. Biomol. Chem., 2016, 14, 1559
    DOI: 10.1039/C5OB02482J

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