Issue 2, 2016

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

Abstract

A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.

Graphical abstract: A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

Supplementary files

Article information

Article type
Communication
Submitted
14 Oct 2015
Accepted
05 Nov 2015
First published
05 Nov 2015
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2016,14, 430-433

Author version available

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

M. E. Due-Hansen, S. K. Pandey, E. Christiansen, R. Andersen, S. V. F. Hansen and T. Ulven, Org. Biomol. Chem., 2016, 14, 430 DOI: 10.1039/C5OB02129D

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