Issue 2, 2016
From the journal:

Organic & Biomolecular Chemistry

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates†

Maria E. Due-Hansen,a   Sunil K. Pandey,a   Elisabeth Christiansen,a   Rikke Andersen,a   Steffen V. F. Hansena  and  Trond Ulven*a  

* Corresponding authors

a Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
E-mail: ulven@sdu.dk
Fax: +45 6615 8780
Tel: +45 6550 2568

Abstract

A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.

Graphical abstract: A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

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Article information

DOI
https://doi.org/10.1039/C5OB02129D
Article type
Communication
Submitted
14 Oct 2015
Accepted
05 Nov 2015
First published
05 Nov 2015
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2016,14, 430-433

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A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

M. E. Due-Hansen, S. K. Pandey, E. Christiansen, R. Andersen, S. V. F. Hansen and T. Ulven, Org. Biomol. Chem., 2016, 14, 430 DOI: 10.1039/C5OB02129D

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