Issue 3, 2016
From the journal:

Organic & Biomolecular Chemistry

Pd(ii)-catalyzed intramolecular oxidative Heck dearomative reaction: approach to thiazole-fused pyrrolidinones with a C2-azaquarternary center†

Shang Gao,a   Chi Yang,a   Yue Huang,a   Lei Zhao,a   Xiaoming Wu,a   Hequan Yao*a  and  Aijun Lin*a  

* Corresponding authors

a State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China
E-mail: ajlin@cpu.edu.cn, hyao@cpu.edu.cn

Abstract

A Pd(II)-catalyzed intramolecular oxidative Heck dearomative reaction for the construction of thiazole-fused pyrrolidinones with a C2-azaquarternary center and C3-exo-double bond has been achieved for the first time. The reaction exhibited good functional group tolerance and gram-scale capacity.

Graphical abstract: Pd(ii)-catalyzed intramolecular oxidative Heck dearomative reaction: approach to thiazole-fused pyrrolidinones with a C2-azaquarternary center

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Article information

DOI
https://doi.org/10.1039/C5OB01970B
Article type
Communication
Submitted
21 Sep 2015
Accepted
20 Nov 2015
First published
23 Nov 2015

Org. Biomol. Chem., 2016,14, 840-843

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Pd(II)-catalyzed intramolecular oxidative Heck dearomative reaction: approach to thiazole-fused pyrrolidinones with a C2-azaquarternary center

S. Gao, C. Yang, Y. Huang, L. Zhao, X. Wu, H. Yao and A. Lin, Org. Biomol. Chem., 2016, 14, 840 DOI: 10.1039/C5OB01970B

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