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Issue 24, 2016
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Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes

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Abstract

A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families.

Graphical abstract: Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 02 Sep 2015, accepted on 22 Sep 2015 and first published on 30 Sep 2015


Article type: Communication
DOI: 10.1039/C5OB01837D
Citation: Org. Biomol. Chem., 2016,14, 5477-5480
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    Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes

    E. M. Rigsbee, C. Zhou, C. M. Rasik, A. Z. Spitz, A. J. Nichols and M. K. Brown, Org. Biomol. Chem., 2016, 14, 5477
    DOI: 10.1039/C5OB01837D

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