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Issue 44, 2016
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Cell micropatterns based on silicone-oil-modified slippery surfaces

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Abstract

We demonstrate a simple and environment-friendly strategy to fabricate cell micropatterns on a nanodendritic superhydrophilic silica substrate separated by silicone-oil-modified superhydrophobic barriers. The superhydrophilic spots exhibit excellent cell adhesion capability due to the enhanced local topographic interaction between cell filopodia and the nanodendritic substrate interface, and result in sensational cell micropatterns. In contrast, the anti-adhesion of silicone-oil-modified superhydrophobic barriers prevents cell migration and results in long-term cell-repellency. Such superhydrophilic spots and silicone-oil-modified superhydrophobic barriers are very helpful for the formation of cell micropatterns. Moreover, co-culture of different cells can be achieved on the silicone-oil-modified micropatterns. The unique properties of our silicone-oil-modified micropatterns hold considerable promise for a wide range of biological applications, such as cell-based bioassays, tissue engineering, high-throughput screening and fundamental studies of cell biology.

Graphical abstract: Cell micropatterns based on silicone-oil-modified slippery surfaces

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Publication details

The article was received on 22 Sep 2016, accepted on 14 Oct 2016 and first published on 17 Oct 2016


Article type: Communication
DOI: 10.1039/C6NR07498G
Citation: Nanoscale, 2016,8, 18612-18615
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    Cell micropatterns based on silicone-oil-modified slippery surfaces

    W. Shi, T. Xu, L. Xu, Y. Chen, Y. Wen, X. Zhang and S. Wang, Nanoscale, 2016, 8, 18612
    DOI: 10.1039/C6NR07498G

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