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Issue 41, 2016
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Zwitterionic surface coating of quantum dots reduces protein adsorption and cellular uptake

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Abstract

We have studied the effect of the zwitterionic surface coating of quantum dots (QDs) on their interaction with a serum supplemented cell medium and their internalization by human cervical carcinoma (HeLa) cells. Zwitterionic QDs showed negligible adsorption of human serum albumin (HSA) selected as a model serum protein, in contrast to similar but negatively charged QDs. The incorporation of zwitterionic QDs by HeLa cells was found to be lower than for negatively charged QDs and for positively charged QDs, for which the uptake yield was largest. Our results suggest that the suppression of protein adsorption, here accomplished by zwitterionic QD surfaces, offers a strategy that allows for reducing the cellular uptake of nanoparticles.

Graphical abstract: Zwitterionic surface coating of quantum dots reduces protein adsorption and cellular uptake

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Publication details

The article was received on 22 Jul 2016, accepted on 13 Sep 2016 and first published on 14 Sep 2016


Article type: Paper
DOI: 10.1039/C6NR05805A
Citation: Nanoscale, 2016,8, 17794-17800
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    Zwitterionic surface coating of quantum dots reduces protein adsorption and cellular uptake

    S. Ashraf, J. Park, M. A. Bichelberger, K. Kantner, R. Hartmann, P. Maffre, A. H. Said, N. Feliu, J. Lee, D. Lee, G. U. Nienhaus, S. Kim and W. J. Parak, Nanoscale, 2016, 8, 17794
    DOI: 10.1039/C6NR05805A

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