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Issue 43, 2016
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A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets

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Abstract

We develop a versatile recognition system based on 3D triangular-shaped DNA nanotubes by integrating three different aptamer sequences along the three edges. This would allow multiple binding activities to be combined into a single system. The versatility of this nanotube platform can also provide a framework for spatial orientation and positioning of different aptamer-binding ligands in a ‘pea-pod’ architecture.

Graphical abstract: A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets

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Publication details

The article was received on 08 Jul 2016, accepted on 11 Oct 2016 and first published on 11 Oct 2016


Article type: Communication
DOI: 10.1039/C6NR05411K
Citation: Nanoscale, 2016,8, 18291-18295
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    A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets

    Z. Dai, Q. Gao, M. C. Cheung, H. M. Leung, T. C. K. Lau, H. F. Sleiman, K. W. C. Lai and P. K. Lo, Nanoscale, 2016, 8, 18291
    DOI: 10.1039/C6NR05411K

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