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Issue 34, 2016
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Nanoparticles assembled via pH-responsive reversible segregation of cyclodextrins in polyrotaxanes

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Abstract

Supramolecular polymers with monomers bound together by secondary interactions, such as polyrotaxanes (PRXs), consisting of alpha cyclodextrin (αCD) threaded onto poly(ethylene glycol) (PEG), have attracted interest as a result of their ability to overcome physical limitations present in conventional, covalently structured polymers. Herein, we describe the formation of pH-responsive supramolecular assemblies from carboxyethylester bearing αCD and PEG PRXs. These PRXs were formed using PEG of Mw 20 kDa and a threading degree of 28%. Upon charge neutralisation the threaded αCDs co-localise, resulting in aggregation of the PRXs and the formation of a suspension by self-assembly. This process is shown to be reversible and possible via the mobility of CDs along the PEG guest chain. As a result of the inherent properties of PRXs, such as enhanced multivalent interactions and degradation, these responsive supramolecular polymers are expected to be of interest in fields where PRX-based materials have already found application, including paints, self-healing materials, surface coatings, and polymer therapeutics.

Graphical abstract: Nanoparticles assembled via pH-responsive reversible segregation of cyclodextrins in polyrotaxanes

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Publication details

The article was received on 16 Jun 2016, accepted on 01 Aug 2016 and first published on 11 Aug 2016


Article type: Paper
DOI: 10.1039/C6NR04841B
Citation: Nanoscale, 2016,8, 15589-15596
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    Nanoparticles assembled via pH-responsive reversible segregation of cyclodextrins in polyrotaxanes

    B. L. Tardy, S. Tan, H. H. Dam, H. Ejima, A. Blencowe, G. G. Qiao and F. Caruso, Nanoscale, 2016, 8, 15589
    DOI: 10.1039/C6NR04841B

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