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Issue 36, 2016
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Direct real-time detection of single proteins using silicon nanowire-based electrical circuits

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Abstract

We present an efficient strategy through surface functionalization to build a single silicon nanowire field-effect transistor-based biosensor that is capable of directly detecting protein adsorption/desorption at the single-event level. The step-wise signals in real-time detection of His-tag F1-ATPases demonstrate a promising electrical biosensing approach with single-molecule sensitivity, thus opening up new opportunities for studying single-molecule biophysics in broad biological systems.

Graphical abstract: Direct real-time detection of single proteins using silicon nanowire-based electrical circuits

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Publication details

The article was received on 20 May 2016, accepted on 18 Aug 2016 and first published on 19 Aug 2016


Article type: Communication
DOI: 10.1039/C6NR04103E
Citation: Nanoscale, 2016,8, 16172-16176
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    Direct real-time detection of single proteins using silicon nanowire-based electrical circuits

    J. Li, G. He, H. Ueno, C. Jia, H. Noji, C. Qi and X. Guo, Nanoscale, 2016, 8, 16172
    DOI: 10.1039/C6NR04103E

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