Self-assembly of high-nuclearity lanthanide-based nanoclusters for potential bioimaging applications

Xiaoping Yang; Shiqing Wang; Desmond Schipper; Lijie Zhang; Zongping Li; Shaoming Huang; Daqiang Yuan; Zhongning Chen; Annie J. Gnanam; Justin W. Hall; Tyler L. King; Emily Que; Yakhya Dieye; Jamuna Vadivelu; Katherine A. Brown; Richard A. Jones

doi:10.1039/C6NR00642F

Self-assembly of high-nuclearity lanthanide-based nanoclusters for potential bioimaging applications†

Xiaoping Yang,*^ab Shiqing Wang,^ab Desmond Schipper,^c Lijie Zhang,^ab Zongping Li,^ab Shaoming Huang,*^ab Daqiang Yuan,

^d Zhongning Chen,*^d Annie J. Gnanam,^c Justin W. Hall,^c Tyler L. King,^c Emily Que,^c Yakhya Dieye,^e Jamuna Vadivelu,^e Katherine A. Brown^cf and Richard A. Jones*^c

Author affiliations

* Corresponding authors

^a College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China

^b Zhejiang Key Laboratory of Carbon Materials, Wenzhou 325035, China
E-mail: xpyang@wzu.edu.cn, smhuang@wzu.edu.cn
Tel: +86 577 88373064

^c The University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station A5300, Austin, Texas, USA
E-mail: rajones@cm.utexas.edu
Tel: +1 512 4711706

^d Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences. Fuzhou 350002, China
E-mail: czn@fjirsm.ac.cn

^e Department of Medical Microbiology, University of Malaya, Kuala Lumpur 50603, Malaysia

^f Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK

Abstract

Two series of Cd–Ln and Ni–Ln clusters [Ln₈Cd₂₄L₁₂(OAc)₄₄₍₄₈₎Cl₄₍₀₎] and [Ln₈Ni₆L₆(OAc)₂₄(EtOH)₆(H₂O)₂] were constructed using a flexible ligand. The Cd–Ln clusters exhibit interesting nano-drum-like structures which allows direct visualization by TEM. Luminex MicroPlex Microspheres loaded with the Cd–Sm cluster were visualized using epifluorescence microscopy. Cytotoxicity studies on A549 and AGS cancer cell lines showed that the materials have mild to moderate cytotoxicity.

Nanoscale

Self-assembly of high-nuclearity lanthanide-based nanoclusters for potential bioimaging applications†

Abstract

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