Issue 20, 2016

The evolution of gadolinium based contrast agents: from single-modality to multi-modality

Abstract

Gadolinium-based contrast agents are extensively used as magnetic resonance imaging (MRI) contrast agents due to their outstanding signal enhancement and ease of chemical modification. However, it is increasingly recognized that information obtained from single modal molecular imaging cannot satisfy the higher requirements on the efficiency and accuracy for clinical diagnosis and medical research, due to its limitation and default rooted in single molecular imaging technique itself. To compensate for the deficiencies of single function magnetic resonance imaging contrast agents, the combination of multi-modality imaging has turned to be the research hotpot in recent years. This review presents an overview on the recent developments of the functionalization of gadolinium-based contrast agents, and their application in biomedicine applications.

Graphical abstract: The evolution of gadolinium based contrast agents: from single-modality to multi-modality

Article information

Article type
Review Article
Submitted
12 Jan 2016
Accepted
03 May 2016
First published
03 May 2016

Nanoscale, 2016,8, 10491-10510

The evolution of gadolinium based contrast agents: from single-modality to multi-modality

L. Zhang, R. Liu, H. Peng, P. Li, Z. Xu and A. K. Whittaker, Nanoscale, 2016, 8, 10491 DOI: 10.1039/C6NR00267F

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