Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 16, 2016
Previous Article Next Article

Steering microtubule shuttle transport with dynamically controlled magnetic fields

Author affiliations

Abstract

Nanoscale control of matter is critical to the design of integrated nanosystems. Here, we describe a method to dynamically control directionality of microtubule (MT) motion using programmable magnetic fields. MTs are combined with magnetic quantum dots (i.e., MagDots) that are manipulated by external magnetic fields provided by magnetic nanowires. MT shuttles thus undergo both ATP-driven and externally-directed motion with a fluorescence component that permits simultaneous visualization of shuttle motion. This technology is used to alter the trajectory of MTs in motion and to pin MT motion. Such an approach could be used to evaluate the MT–kinesin transport system and could serve as the basis for improved lab-on-a-chip technologies based on MT transport.

Graphical abstract: Steering microtubule shuttle transport with dynamically controlled magnetic fields

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 01 Dec 2015, accepted on 22 Mar 2016 and first published on 23 Mar 2016


Article type: Paper
DOI: 10.1039/C5NR08529B
Citation: Nanoscale, 2016,8, 8641-8649
  •   Request permissions

    Steering microtubule shuttle transport with dynamically controlled magnetic fields

    K. D. Mahajan, G. Ruan, C. J. Dorcéna, G. Vieira, G. Nabar, N. F. Bouxsein, J. J. Chalmers, G. D. Bachand, R. Sooryakumar and J. O. Winter, Nanoscale, 2016, 8, 8641
    DOI: 10.1039/C5NR08529B

Search articles by author