Hydrophilic GO/Fe3O4/Au/PEG nanocomposites for highly selective enrichment of glycopeptides

Bo Jiang; Qi Wu; Nan Deng; Yuanbo Chen; Lihua Zhang; Zhen Liang; Yukui Zhang

doi:10.1039/C5NR08126B

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Hydrophilic GO/Fe₃O₄/Au/PEG nanocomposites for highly selective enrichment of glycopeptides†

Bo Jiang,^a Qi Wu,^a Nan Deng,^a Yuanbo Chen,^a Lihua Zhang,*^a Zhen Liang^a and Yukui Zhang^a

Author affiliations

* Corresponding authors

^a National Chromatographic R. & A. Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023, China
E-mail: lihuazhang@dicp.ac.cn
Fax: +86-411-84379720

Abstract

GO/Fe₃O₄/Au/PEG nanocomposites were synthesized via bonding gold nanoparticles on magnetic graphene oxide using polyethylenimine as the reducing and immobilizing reagent, followed by thiol-terminal polyethylene glycol immobilization. With the use of this nanocomposite, 255 glycopeptides, mapped to 127 different glycoproteins, were identified from human serum, demonstrating its great potential for glycosylation analysis.

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Article information

DOI: https://doi.org/10.1039/C5NR08126B
Article type: Communication
Submitted: 17 Nov 2015
Accepted: 02 Feb 2016
First published: 02 Feb 2016

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Nanoscale, 2016,8, 4894-4897

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Hydrophilic GO/Fe₃O₄/Au/PEG nanocomposites for highly selective enrichment of glycopeptides

B. Jiang, Q. Wu, N. Deng, Y. Chen, L. Zhang, Z. Liang and Y. Zhang, Nanoscale, 2016, 8, 4894 DOI: 10.1039/C5NR08126B

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