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Issue 11, 2016
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Structural and mechanistic diversity of multidrug transporters

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Abstract

Covering: 2009 to mid 2016

Multidrug transporters are common and prevalent in all orders of life, having diverse functions from the removal of toxins, resistance to cytotoxins, and the transport of specific eluents. In addition, multidrug transporters pose a significant threat to modern medicine. Able to transport structurally diverse small molecule drugs, these transporters are implicated in antibiotic resistant strains of bacteria, as well as chemotherapeutic-resistance cancer cells. Although important in such resistance, a relatively small number of multidrug transporters have been structurally characterized, primarily due to the difficulty in purifying and crystallizing active membrane proteins and protein complexes. This review will cover recent structural breakthroughs in the past six years that have led to increased knowledge of the mechanisms of multidrug transporter chemistry, and the role of these transporters in exporting secondary metabolites.

Graphical abstract: Structural and mechanistic diversity of multidrug transporters

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Publication details

The article was received on 15 Jan 2016 and first published on 29 Jul 2016


Article type: Review Article
DOI: 10.1039/C6NP00006A
Citation: Nat. Prod. Rep., 2016,33, 1255-1267
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    Structural and mechanistic diversity of multidrug transporters

    J. J. Mousa and S. D. Bruner, Nat. Prod. Rep., 2016, 33, 1255
    DOI: 10.1039/C6NP00006A

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