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Issue 6, 2016
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Molecular imaging probes derived from natural peptides

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Abstract

Covering: up to the end of 2015.

Peptides are naturally occurring compounds that play an important role in all living systems and are responsible for a range of essential functions. Peptide receptors have been implicated in disease states such as oncology, metabolic disorders and cardiovascular disease. Therefore, natural peptides have been exploited as diagnostic and therapeutic agents due to the unique target specificity for their endogenous receptors. This review discusses a variety of natural peptides highlighting their discovery, endogenous receptors, as well as their derivatization to create molecular imaging agents, with an emphasis on the design of radiolabelled peptides. This review also highlights methods for discovering new and novel peptides when knowledge of specific targets and endogenous ligands are not available.

Graphical abstract: Molecular imaging probes derived from natural peptides

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Publication details

The article was received on 28 Jul 2015 and first published on 25 Feb 2016


Article type: Review Article
DOI: 10.1039/C5NP00083A
Citation: Nat. Prod. Rep., 2016,33, 761-800
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    Molecular imaging probes derived from natural peptides

    C. L. Charron, J. L. Hickey, T. K. Nsiama, D. R. Cruickshank, W. L. Turnbull and L. G. Luyt, Nat. Prod. Rep., 2016, 33, 761
    DOI: 10.1039/C5NP00083A

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