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Issue 11, 2016
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Thiosemicarbazone-derived copper(II), cobalt(II) and nickel(II) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies

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Abstract

Copper(II), cobalt(II) and nickel (II) complexes (1–6) of 1-[amino(thioxo)methyl]-5-hydroxy-3-methyl-1H-pyrazole have been synthesized and characterized by IR, UV-Vis, NMR, ESI-MS and elemental analysis. Ligand and metal(II) complexes have been screened for their toxic effect on HeLa and K562 cancer cell lines, as well as on normal HUVEC cells. Cytotoxic effectiveness of copper(II) complexes (1 and 4) (IC50 2–5 μM after 48 h) was 4–50 times higher than that of other complexes and cisplatin. These complexes were non-toxic to primary human endothelial cells. For these complexes, induction of cell apoptosis by the caspase 3/7 assay has been measured. The interactions with DNA by the enzymatic method have also been investigated.

Graphical abstract: Thiosemicarbazone-derived copper(ii), cobalt(ii) and nickel(ii) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies

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Publication details

The article was received on 15 Sep 2016, accepted on 30 Sep 2016 and first published on 17 Oct 2016


Article type: Paper
DOI: 10.1039/C6NJ02899C
Citation: New J. Chem., 2016,40, 9761-9767
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    Thiosemicarbazone-derived copper(II), cobalt(II) and nickel(II) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies

    M. Sobiesiak, M. Cieślak, K. Królewska, J. Kaźmierczak-Barańska, B. Pasternak and E. Budzisz, New J. Chem., 2016, 40, 9761
    DOI: 10.1039/C6NJ02899C

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