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Issue 11, 2016
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A three-dimensional Nd(III)-based metal–organic framework as a smart drug carrier

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Abstract

A 3D lanthanide metal–organic framework (MOF) with the formula [Nd2(abtc)1.5(H2O)3(DMA)]·H2O·DMA (1) [H4abtc = 3,3′,5,5′-azobenzenetetracarboxylic acid; DMA = N,N-dimethylacetamide] has been synthesized under solvothermal conditions and characterized. The efficient encapsulation and controllable release of an anticancer drug (5-Fu) make it a promising drug delivery host. The in vitro cytotoxicity of 1 and 5-Fu loaded 1a were also evaluated using MTT assays against HeLa cells.

Graphical abstract: A three-dimensional Nd(iii)-based metal–organic framework as a smart drug carrier

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Publication details

The article was received on 15 Jul 2016, accepted on 12 Sep 2016 and first published on 13 Sep 2016


Article type: Letter
DOI: 10.1039/C6NJ02221A
Citation: New J. Chem., 2016,40, 9017-9020
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    A three-dimensional Nd(III)-based metal–organic framework as a smart drug carrier

    P. Du, W. Gu and X. Liu, New J. Chem., 2016, 40, 9017
    DOI: 10.1039/C6NJ02221A

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