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Issue 12, 2016
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Cu(II) complex of a new isoindole derivative: structure, catecholase like activity, antimicrobial properties and bio-molecular interactions

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Abstract

An isoindole based Cu(II) complex, [Cu(PICPH)Cl2], was synthesized in situ by reacting copper(II) chloride with a pyridine derived ligand, PICPH. The complex was characterized by spectroscopic techniques while its structure was confirmed by single crystal X-ray diffraction analysis. The complex has a trigonal bipyramid geometry containing both five- and seven-member chelate rings. It shows catecholase-like activity. Interaction of the complex with a bio-relevant antipyrine derivative (ANNAP) was studied using fluorescence spectroscopy. DFT studies unfold the energetics associated with PICPH, [Cu(PICPH)Cl2] and the adduct between [Cu(PICPH)Cl2] and ANNAP. Antimicrobial activities of the compounds were also studied.

Graphical abstract: Cu(ii) complex of a new isoindole derivative: structure, catecholase like activity, antimicrobial properties and bio-molecular interactions

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Publication details

The article was received on 14 Jul 2016, accepted on 11 Oct 2016 and first published on 12 Oct 2016


Article type: Paper
DOI: 10.1039/C6NJ02193J
Citation: New J. Chem., 2016,40, 10094-10099
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    Cu(II) complex of a new isoindole derivative: structure, catecholase like activity, antimicrobial properties and bio-molecular interactions

    S. Adhikari, S. Lohar, B. Kumari, A. Banerjee, R. Bandopadhyay, J. S. Matalobos and D. Das, New J. Chem., 2016, 40, 10094
    DOI: 10.1039/C6NJ02193J

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