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Issue 11, 2016
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Tuning the sensing range of potassium ions by changing the loop size of G-quadruplex sensors

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Abstract

Here, the effect of loop size in a series of G-quadruplex ((G3T2A)3G3, (G3T2)3G3 and (G3T)3G3) sensors on sensing ability for potassium ions (K+) was evaluated. Fluorescence spectroscopy, mass spectrometry, circular dichroism and isothermal titration calorimetry were applied to investigate their different performances. The results demonstrated that the saturation concentration and the response range of K+ changed to higher concentration as the loop size of the G-quadruplex sensor increased. The association constants decreased along with the increase of loop size, hence more potassium ions were needed for the equilibrium which agreed with their different sensing ranges. In brief, varying loop sizes of the G-quadruplex can efficiently tune the stability of the G-quadruplex and the sensing range of potassium ions. This may guide the design of a new G-quadruplex sensor.

Graphical abstract: Tuning the sensing range of potassium ions by changing the loop size of G-quadruplex sensors

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Publication details

The article was received on 09 Jul 2016, accepted on 06 Sep 2016 and first published on 07 Sep 2016


Article type: Paper
DOI: 10.1039/C6NJ02136K
Citation: New J. Chem., 2016,40, 9285-9290
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    Tuning the sensing range of potassium ions by changing the loop size of G-quadruplex sensors

    T. Wu, C. Zhang, Z. Wang, H. Ren, Y. Kang and Y. Du, New J. Chem., 2016, 40, 9285
    DOI: 10.1039/C6NJ02136K

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