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Issue 11, 2016
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Improved photodynamic activity of a dual phthalocyanine–ALA photosensitiser

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Abstract

A phthalocyanine–ALA conjugate showed an improved photoinduced cell killing efficiency due to the combined action of the phthalocyanine core and protoporphyrin IX, which was biosynthesised intracellularly by using released ALA as a substrate. The intracellular presence of two photosensitisers and their joint excitation induced a synergistic efficiency for cell killing. The construction of photosensitisers that release intracellular ALA holds great potential for the development of more efficient PDT photosensitisers.

Graphical abstract: Improved photodynamic activity of a dual phthalocyanine–ALA photosensitiser

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Publication details

The article was received on 04 Jul 2016, accepted on 27 Sep 2016 and first published on 28 Sep 2016


Article type: Paper
DOI: 10.1039/C6NJ02073A
Citation: New J. Chem., 2016,40, 9666-9671
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    Improved photodynamic activity of a dual phthalocyanine–ALA photosensitiser

    C. Pavani, C. M. L. Francisco, N. R. S. Gobo, K. T. de Oliveira and M. S. Baptista, New J. Chem., 2016, 40, 9666
    DOI: 10.1039/C6NJ02073A

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