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Issue 11, 2016
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Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis

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Abstract

The current study involves the synthesis of novel imidazo[4,5-c]pyridine derivatives (IPD) containing amide/urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacological activities were determined by the objective to better understand their structure–activity relationship (SAR) for their in vitro antimycobacterial activity against M. tuberculosis. Some synthesized compounds showed significant activity against M. tuberculosis based on the agar dilution method. Among the forty-one compounds screened, compounds 21, 22 and 23 were found to be the most active compounds against M. tuberculosis. In the in vivo animal model, 21, 22 and 23 decreased the bacterial load in lung and spleen tissues at the dose of 50 mg kg−1 body weight.

Graphical abstract: Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis

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Publication details

The article was received on 04 Jul 2016, accepted on 06 Sep 2016 and first published on 09 Sep 2016


Article type: Paper
DOI: 10.1039/C6NJ02069K
Citation: New J. Chem., 2016,40, 9194-9204
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    Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis

    M. Madaiah, M. K. Prashanth, H. D. Revanasiddappa and B. Veeresh, New J. Chem., 2016, 40, 9194
    DOI: 10.1039/C6NJ02069K

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