Jump to main content
Jump to site search

Issue 11, 2016
Previous Article Next Article

Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality

Author affiliations

Abstract

1 : 1 and 2 : 2 oligomeric piperazinophanes with an intraannular ester functionality have been synthesized via Mannich reaction of various aromatic esters with piperazine by a one-pot reaction under benign conditions through the multicomponent reaction methodology. The newly synthesized piperazinophanes were characterized using spectral and analytical methods. The ester based 1 : 1 oligomeric piperazinophanes exhibit good target binding ability in molecular docking studies and also show better antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Streptococcus pyogenes bacteria than the 2 : 2 oligomeric piperazinophanes.

Graphical abstract: Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Jun 2016, accepted on 16 Sep 2016 and first published on 19 Sep 2016


Article type: Paper
DOI: 10.1039/C6NJ01956K
Citation: New J. Chem., 2016,40, 9494-9499
  •   Request permissions

    Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality

    S. Selvarani and P. Rajakumar, New J. Chem., 2016, 40, 9494
    DOI: 10.1039/C6NJ01956K

Search articles by author

Spotlight

Advertisements