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Issue 11, 2016
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Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality

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Abstract

1 : 1 and 2 : 2 oligomeric piperazinophanes with an intraannular ester functionality have been synthesized via Mannich reaction of various aromatic esters with piperazine by a one-pot reaction under benign conditions through the multicomponent reaction methodology. The newly synthesized piperazinophanes were characterized using spectral and analytical methods. The ester based 1 : 1 oligomeric piperazinophanes exhibit good target binding ability in molecular docking studies and also show better antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Streptococcus pyogenes bacteria than the 2 : 2 oligomeric piperazinophanes.

Graphical abstract: Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality

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Publication details

The article was received on 23 Jun 2016, accepted on 16 Sep 2016 and first published on 19 Sep 2016


Article type: Paper
DOI: 10.1039/C6NJ01956K
Citation: New J. Chem., 2016,40, 9494-9499
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    Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality

    S. Selvarani and P. Rajakumar, New J. Chem., 2016, 40, 9494
    DOI: 10.1039/C6NJ01956K

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