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Issue 11, 2016
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Fabrication of a label-free electrochemical immunosensor using a redox active ferrocenyl dendrimer

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Abstract

We report an IgG (=immunoglobulin) electrochemical immunosensor using a newly synthesized redox-active ferrocenyl dendrimer of generation 2 (G2Fc) as a voltammetric transducer. The ferrocenyl dendrimer N(CH2CH2C(O)NHCH2CH2NHC(O)Fe(η5-C5H4)(η5-C5H5))(CH2CH2N(CH2CH2C(O)NHCH2CH2NHC(O)Fe(η5-C5H4)(η5-C5H5))2)2 (G2Fc) was used as a functional moiety to immobilize the antibody on the surface of the electrode. A sandwich immunosensor of the type IgG/Bovine serum albumin (BSA)/anti-IgG/G2Fc/glassy carbon electrode (GCE) was fabricated. The electrochemical properties of G2Fc were thoroughly studied in aqueous and non-aqueous electrolytes with varying scan rates. The incubation time was optimized for better analytical performance of the immunosensor. It is found that the developed amperometric immunosensor is sensitive to a concentration of IgG as low as 2 ng mL−1.

Graphical abstract: Fabrication of a label-free electrochemical immunosensor using a redox active ferrocenyl dendrimer

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Publication details

The article was received on 15 Mar 2016, accepted on 30 Aug 2016 and first published on 31 Aug 2016


Article type: Paper
DOI: 10.1039/C6NJ00830E
Citation: New J. Chem., 2016,40, 9046-9053
  • Open access: Creative Commons BY license
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    Fabrication of a label-free electrochemical immunosensor using a redox active ferrocenyl dendrimer

    S. Chandra, C. Gäbler, C. Schliebe, H. Lang and D. Bahadur, New J. Chem., 2016, 40, 9046
    DOI: 10.1039/C6NJ00830E

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