Issue 2, 2017

Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

Abstract

Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.

Graphical abstract: Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

Supplementary files

Article information

Article type
Communication
Submitted
11 Nov 2016
Accepted
14 Dec 2016
First published
14 Dec 2016
This article is Open Access
Creative Commons BY license

Nanoscale Horiz., 2017,2, 106-109

Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

S. Won, S. Richards, M. Walker and M. I. Gibson, Nanoscale Horiz., 2017, 2, 106 DOI: 10.1039/C6NH00202A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements