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Issue 5, 2016
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Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain

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Abstract

We report the synthesis, characterization, and assessment of a nanoparticle-based RNAi delivery platform that protects siRNA payloads against nuclease-induced degradation and efficiently delivers them to target cells. The nanocarrier is based on biodegradable mesoporous silicon nanoparticles (pSiNPs), where the voids of the nanoparticles are loaded with siRNA and the nanoparticles are encapsulated with graphene oxide nanosheets (GO–pSiNPs). The graphene oxide encapsulant delays release of the oligonucleotide payloads in vitro by a factor of 3. When conjugated to a targeting peptide derived from the rabies virus glycoprotein (RVG), the nanoparticles show 2-fold greater cellular uptake and gene silencing. Intravenous administration of the nanoparticles into brain-injured mice results in substantial accumulation specifically at the site of injury.

Graphical abstract: Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain

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Publication details

The article was received on 06 May 2016, accepted on 14 Jun 2016 and first published on 14 Jun 2016


Article type: Communication
DOI: 10.1039/C6NH00082G
Citation: Nanoscale Horiz., 2016,1, 407-414
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    Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain

    J. Joo, E. J. Kwon, J. Kang, M. Skalak, E. J. Anglin, A. P. Mann, E. Ruoslahti, S. N. Bhatia and M. J. Sailor, Nanoscale Horiz., 2016, 1, 407
    DOI: 10.1039/C6NH00082G

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