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Issue 2, 2016
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In situ formation of peptidic nanofibers can fundamentally optimize the quality of immune responses against HIV vaccine

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Abstract

Herein, we report that the in situ formed peptidic nanofibers facilitate the induction of multiple crucial immunities against HIV DNA vaccine, including polyfunctional T cell response, broad IgG subclasses response, and V1/V2 loop-specific antibody response, all of which can hardly be triggered by HIV DNA vaccine alone. Such novel in situ formation fundamentally overcomes the big hurdle for the applications of such nanofibers, which previously can only trigger these crucial immune responses via adding exogenous alkaline phosphatase. Such robustness of peptidic nanofibers for inducing crucial immune responses may allow better inhibition against HIV than reported materials.

Graphical abstract: In situ formation of peptidic nanofibers can fundamentally optimize the quality of immune responses against HIV vaccine

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Publication details

The article was received on 14 Sep 2015, accepted on 14 Dec 2015 and first published on 14 Dec 2015


Article type: Communication
DOI: 10.1039/C5NH00064E
Citation: Nanoscale Horiz., 2016,1, 135-143
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    In situ formation of peptidic nanofibers can fundamentally optimize the quality of immune responses against HIV vaccine

    Y. Liu, H. Wang, D. Li, Y. Tian, W. Liu, L. Zhang, W. Zheng, Y. Hao, J. Liu, Z. Yang, Y. Shao and X. Jiang, Nanoscale Horiz., 2016, 1, 135
    DOI: 10.1039/C5NH00064E

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