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Issue 4, 2016
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Alpha-synuclein: relating metals to structure, function and inhibition

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Abstract

Alpha-synuclein has long been studied due to its involvement in the progression of Parkinson's disease (PD), a common neurodegenerative disorder, although a consensus on the exact function of this protein is elusive. This protein shows remarkable structural plasticity and this property is important for both correct cellular function and pathological progression of PD. Formation of intracellular oligomeric species within the substantia nigra correlates with disease progression and it has been proposed that formation of a partially folded intermediate is key to the initiation of the fibrillisation process. Many factors can influence changes in the structure of alpha-synuclein such as disease mutations and interaction with metals and neurotransmitters. High concentrations of both dopamine and metals are present in the substantia nigra making this an ideal location for both the structural alteration of alpha-synuclein and the production of toxic oxygen species. The recent proposal that alpha-synuclein is a ferrireductase is important as it can possibly catalyse the formation of such reactive species and as a result exacerbate neurodegeneration.

Graphical abstract: Alpha-synuclein: relating metals to structure, function and inhibition

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Publication details

The article was received on 11 Jan 2016, accepted on 04 Feb 2016 and first published on 11 Feb 2016


Article type: Critical Review
DOI: 10.1039/C6MT00026F
Citation: Metallomics, 2016,8, 385-397
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    Alpha-synuclein: relating metals to structure, function and inhibition

    J. S. McDowall and D. R. Brown, Metallomics, 2016, 8, 385
    DOI: 10.1039/C6MT00026F

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