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Issue 6, 2016
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An antithrombotic hydrogel with thrombin-responsive fibrinolytic activity: breaking down the clot as it forms

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Abstract

A novel concept of a thrombolytic material whose activity is triggered by the generation of a clot/thrombus is developed. The concept is realized using a tissue plasminogen activator (t-PA)-loaded hydrogel crosslinked by a thrombin-cleavable peptide. The hydrogel is shown to release t-PA in serum and dissolve fibrin clots only when thrombin (generated during clot formation) is present.

Graphical abstract: An antithrombotic hydrogel with thrombin-responsive fibrinolytic activity: breaking down the clot as it forms

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Publication details

The article was received on 14 Aug 2016, accepted on 25 Aug 2016 and first published on 25 Aug 2016


Article type: Communication
DOI: 10.1039/C6MH00307A
Citation: Mater. Horiz., 2016,3, 556-562
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    An antithrombotic hydrogel with thrombin-responsive fibrinolytic activity: breaking down the clot as it forms

    H. Du, C. Li, Y. Luan, Q. Liu, W. Yang, Q. Yu, D. Li, J. L. Brash and H. Chen, Mater. Horiz., 2016, 3, 556
    DOI: 10.1039/C6MH00307A

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