Issue 6, 2016

An antithrombotic hydrogel with thrombin-responsive fibrinolytic activity: breaking down the clot as it forms

Abstract

A novel concept of a thrombolytic material whose activity is triggered by the generation of a clot/thrombus is developed. The concept is realized using a tissue plasminogen activator (t-PA)-loaded hydrogel crosslinked by a thrombin-cleavable peptide. The hydrogel is shown to release t-PA in serum and dissolve fibrin clots only when thrombin (generated during clot formation) is present.

Graphical abstract: An antithrombotic hydrogel with thrombin-responsive fibrinolytic activity: breaking down the clot as it forms

Supplementary files

Article information

Article type
Communication
Submitted
14 Aug 2016
Accepted
25 Aug 2016
First published
25 Aug 2016

Mater. Horiz., 2016,3, 556-562

An antithrombotic hydrogel with thrombin-responsive fibrinolytic activity: breaking down the clot as it forms

H. Du, C. Li, Y. Luan, Q. Liu, W. Yang, Q. Yu, D. Li, J. L. Brash and H. Chen, Mater. Horiz., 2016, 3, 556 DOI: 10.1039/C6MH00307A

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