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Issue 1, 2017
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Evaluation of intoxicating effects of liquor products on drunken mice

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Abstract

Consumption of alcoholic beverages increases the risk of human health problems such as liver, heart and blood vessel diseases. In the present study, the concept of intoxicating degree (ID) is proposed as an index to demonstrate the degree of intoxicating activity for consuming liquor products. A mice model was designed for the evaluation of liquor product IDs. The intoxicating effects of liquor products were investigated by blood alcohol concentrations (BAC) and behaviour abilities of mice including righting reflex, running and forced-swim abilities. A linear regression model between comprehensive drunkenness degree (CD), calculated by integrating BAC and the behaviour abilities, and alcohol-feeding dosages (W), was established (with R2 > 0.9) with a slope factor of K. The ratio of the K values of liquor products to that of purified alcohol could be used to express the ID. For ID values less than 1, the liquor product would have a lower intoxicating effect when the same amount of alcohol content was consumed and vice versa.

Graphical abstract: Evaluation of intoxicating effects of liquor products on drunken mice

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Publication details

The article was received on 30 Aug 2016, accepted on 30 Sep 2016 and first published on 05 Oct 2016


Article type: Research Article
DOI: 10.1039/C6MD00491A
Citation: Med. Chem. Commun., 2017,8, 122-129
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    Evaluation of intoxicating effects of liquor products on drunken mice

    Z. Wu, X. Tian, S. He, L. Quan, Y. Wei and Z. Wu, Med. Chem. Commun., 2017, 8, 122
    DOI: 10.1039/C6MD00491A

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