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Issue 12, 2016
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Liposome antibody–ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration

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Abstract

Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized. They represent a new class of antibody–drug conjugates because carnosine acts as an ionophore for Cu2+ or Zn2+, altering the metallostasis of cancer cells, leading to their death.

Graphical abstract: Liposome antibody–ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration

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Publication details

The article was received on 13 Aug 2016, accepted on 27 Sep 2016 and first published on 28 Sep 2016


Article type: Research Article
DOI: 10.1039/C6MD00461J
Citation: Med. Chem. Commun., 2016,7, 2364-2367
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    Liposome antibody–ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration

    A. Accardo, L. Del Zoppo, G. Morelli, D. F. Condorelli, V. Barresi, N. Musso, G. Spampinato, F. Bellia, G. Tabbì and E. Rizzarelli, Med. Chem. Commun., 2016, 7, 2364
    DOI: 10.1039/C6MD00461J

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