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Issue 11, 2016
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Novel and less explored chemotypes of natural origin for the inhibition of Hsp90

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Abstract

The Hsp90 chaperone is a promising target for the treatment of cancer. Well known inhibitors, e.g. geldanamycin, radicicol, novobiocin and their derivatives, have been extensively investigated and optimized as inhibitors of Hsp90. More recently, new chemotypes of natural origin were reported to modulate Hsp90 function via various and often “non-conventional” mechanisms. This review focuses on these novel classes of natural products whose structures have not yet been thoroughly explored for medicinal chemistry purposes. These novel chemotypes may constitute interesting starting points for future drug discovery campaigns.

Graphical abstract: Novel and less explored chemotypes of natural origin for the inhibition of Hsp90

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Publication details

The article was received on 17 Jun 2016, accepted on 12 Jul 2016 and first published on 13 Jul 2016


Article type: Review Article
DOI: 10.1039/C6MD00340K
Citation: Med. Chem. Commun., 2016,7, 2063-2075
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    Novel and less explored chemotypes of natural origin for the inhibition of Hsp90

    F. Pellati and G. Rastelli, Med. Chem. Commun., 2016, 7, 2063
    DOI: 10.1039/C6MD00340K

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