High throughput screening of a 4096 compound library of boronic acid and acridine containing branched peptides revealed compounds that have dissociation constants in the low nanomolar regime for HIV-1 RRE IIB RNA. We demonstrate that branched peptide boronic acids A5, A6, and A7 inhibit the production of p24, an HIV-1 capsid protein, in a dose-dependent manner.
J. E. Wynn, W. Zhang, D. M. Tebit, L. R. Gray, M. Hammarskjold, D. Rekosh and W. L. Santos, Med. Chem. Commun., 2016, 7, 1436 DOI: 10.1039/C6MD00171H
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