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Issue 5, 2016
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Efficacy of a novel ferrocenyl diaryl butene citrate compound as a biocide for preventing healthcare-associated infections

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Abstract

The antiseptic and disinfectant potential of a formulation containing the tamoxifen analogue 1,1-bis[4-(3-dimethylaminopropoxy)phenyl]-2-ferrocenyl-but-1-ene citrate was assessed according to European standards and pharmacopeia in comparison with a commercial antiseptic product containing hexamidine diisethionate, chlorhexidine digluconate and chlorocresol as active ingredients. The formulation met the phase 1 requirement of reducing by 5 cycles the counts of microorganisms frequently involved in healthcare-associated infections, namely Escherichia coli ATCC 10536, Pseudomonas aeruginosa ATCC 15442, Staphylococcus aureus ATCC 6538, Enterococcus hirae ATCC 10541 and Candida albicans ATCC 10231. It also killed a clinical isolate of Acinetobacter baumannii which is highly resistant to antibiotics and antiseptics. In phase 2/step 2 tests, it reduced the counts of E. coli ATCC 10536 by 4 log cycles within 60 seconds on hands (standard EN 1499). The novel formula is a potent biocide, and this demonstration could lead to the development of a new commercial antiseptic.

Graphical abstract: Efficacy of a novel ferrocenyl diaryl butene citrate compound as a biocide for preventing healthcare-associated infections

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Publication details

The article was received on 08 Jan 2016, accepted on 23 Feb 2016 and first published on 24 Feb 2016


Article type: Research Article
DOI: 10.1039/C5MD00568J
Citation: Med. Chem. Commun., 2016,7, 948-954
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    Efficacy of a novel ferrocenyl diaryl butene citrate compound as a biocide for preventing healthcare-associated infections

    M. El Arbi, K. Jalléli, F. Trigui, P. Pigeon, M. Görmen, S. Top, S. Aifa, I. Fliss, G. Jaouen and R. Hammami, Med. Chem. Commun., 2016, 7, 948
    DOI: 10.1039/C5MD00568J

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