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Issue 3, 2016
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Rigid amphipathic nucleosides suppress reproduction of the tick-borne encephalitis virus

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Abstract

Rigid amphipathic fusion inhibitors (RAFIs), 5-arylethynyl uracil nucleosides with bulky aryl groups, appeared to have considerable activity against tick-borne encephalitis virus (TBEV) in cell culture. The rigid ethynyl linker and perylene residue are essential structural prerequisites for high activity, giving EC50 values of 18 and 24 nM for 5-(perylen-3-yl)ethynyl-arabino-uridine and 5-(perylen-3-yl)ethynyl-2′-deoxy-uridine, respectively, upon simultaneous mixing of the compounds, cells and virus.

Graphical abstract: Rigid amphipathic nucleosides suppress reproduction of the tick-borne encephalitis virus

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Publication details

The article was received on 20 Nov 2015, accepted on 18 Dec 2015 and first published on 21 Dec 2015


Article type: Research Article
DOI: 10.1039/C5MD00538H
Citation: Med. Chem. Commun., 2016,7, 495-499
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    Rigid amphipathic nucleosides suppress reproduction of the tick-borne encephalitis virus

    A. A. Orlov, A. A. Chistov, L. I. Kozlovskaya, A. V. Ustinov, V. A. Korshun, G. G. Karganova and D. I. Osolodkin, Med. Chem. Commun., 2016, 7, 495
    DOI: 10.1039/C5MD00538H

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