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Issue 1, 2016
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Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

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Abstract

A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containing an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant F. philomiragia.

Graphical abstract: Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

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The article was received on 18 Aug 2015, accepted on 18 Sep 2015 and first published on 30 Sep 2015


Article type: Concise Article
DOI: 10.1039/C5MD00353A
Author version available: Download Author version (PDF)
Citation: Med. Chem. Commun., 2016,7, 128-131
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    Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

    M. D. Stephens, V. B. Hubble, R. K. Ernst, M. L. van Hoek, R. J. Melander, J. Cavanagh and C. Melander, Med. Chem. Commun., 2016, 7, 128
    DOI: 10.1039/C5MD00353A

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