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Issue 12, 2016
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Characterization of human pineal gland proteome

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Abstract

The pineal gland is a neuroendocrine gland located at the center of the brain. It is known to regulate various physiological functions in the body through secretion of the neurohormone melatonin. Comprehensive characterization of the human pineal gland proteome has not been undertaken to date. We employed a high-resolution mass spectrometry-based approach to characterize the proteome of the human pineal gland. A total of 5874 proteins were identified from the human pineal gland in this study. Of these, 5820 proteins were identified from the human pineal gland for the first time. Interestingly, 1136 proteins from the human pineal gland were found to contain a signal peptide domain, which indicates the secretory nature of these proteins. An unbiased global proteomic profile of this biomedically important organ should benefit molecular research to unravel the role of the pineal gland in neuropsychiatric and neurodegenerative diseases.

Graphical abstract: Characterization of human pineal gland proteome

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Publication details

The article was received on 02 Jul 2016, accepted on 20 Sep 2016 and first published on 20 Sep 2016


Article type: Paper
DOI: 10.1039/C6MB00507A
Citation: Mol. BioSyst., 2016,12, 3622-3632
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    Characterization of human pineal gland proteome

    S. D. Yelamanchi, M. Kumar, A. K. Madugundu, L. Gopalakrishnan, G. Dey, S. Chavan, G. Sathe, P. P. Mathur, H. Gowda, A. Mahadevan, S. K. Shankar and T. S. K. Prasad, Mol. BioSyst., 2016, 12, 3622
    DOI: 10.1039/C6MB00507A

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