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Issue 23, 2016
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DROPLAY: laser writing of functional patterns within biological microdroplet displays

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Abstract

In this study, we introduce an optofluidic method for the rapid construction of large-area cell-sized droplet assemblies with user-defined, re-writable, two-dimensional patterns of functional droplets. Light responsive water-in-oil droplets capable of releasing fluorescent dye molecules upon exposure were generated and self-assembled into arrays inside a microfluidic device. This biological architecture was exploited by the scanning laser of a confocal microscope to ‘write’ user defined patterns of differentiated (fluorescent) droplets in a network of originally undifferentiated (non-fluorescent) droplets. As a result, long lasting images were produced on a droplet fabric with droplets acting as pixels of a biological monitor, which can be erased and re-written on-demand. Regio-specific light-induced droplet differentiation within a large population of droplets provides a new paradigm for the rapid construction of bio-synthetic systems with potential as tissue mimics and biological display materials.

Graphical abstract: DROPLAY: laser writing of functional patterns within biological microdroplet displays

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Publication details

The article was received on 28 Sep 2016, accepted on 18 Oct 2016 and first published on 18 Oct 2016


Article type: Paper
DOI: 10.1039/C6LC01219A
Citation: Lab Chip, 2016,16, 4621-4627
  • Open access: Creative Commons BY license
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    DROPLAY: laser writing of functional patterns within biological microdroplet displays

    C. L. Chan, G. Bolognesi, A. Bhandarkar, M. S. Friddin, N. J. Brooks, J. M. Seddon, R. V. Law, L. M. C. Barter and O. Ces, Lab Chip, 2016, 16, 4621
    DOI: 10.1039/C6LC01219A

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