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Issue 22, 2016
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A simple check valve for microfluidic point of care diagnostics

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Abstract

Check valves are often essential components in microfluidic devices, enabling automated sample processing for diagnostics at the point of care. However, there is an unmet need for a check valve design that is compatible with rigid thermoplastic devices during all stages of development—from initial prototyping with a laser cutter to final production with injection molding. Here, we present simple designs for a passive, normally closed check valve that is manufactured from commonly available materials with a CO2 laser and readily integrated into prototype and production thermoplastic devices. The check valve consists of a thermoplastic planar spring and a soft elastomeric pad that act together to seal against fluid backflow. The valve's cracking pressure can be tuned by modifying the spring's planar geometry and thickness. Seal integrity is improved with the addition of a raised annular boss beneath the elastomeric pad. To demonstrate the valve's usefulness, we employ these valves to create a finger-operated on-chip reagent reservoir and a finger-actuated pneumatic pump. We also apply this check valve to passively seal a device to enable portable detection of RNA from West Nile virus in a laser-cut device.

Graphical abstract: A simple check valve for microfluidic point of care diagnostics

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Publication details

The article was received on 02 Sep 2016, accepted on 13 Oct 2016 and first published on 14 Oct 2016


Article type: Paper
DOI: 10.1039/C6LC01104G
Citation: Lab Chip, 2016,16, 4436-4444
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    A simple check valve for microfluidic point of care diagnostics

    C. S. Ball, R. F. Renzi, A. Priye and R. J. Meagher, Lab Chip, 2016, 16, 4436
    DOI: 10.1039/C6LC01104G

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