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Issue 13, 2016
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High density 3D printed microfluidic valves, pumps, and multiplexers

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Abstract

In this paper we demonstrate that 3D printing with a digital light processor stereolithographic (DLP-SLA) 3D printer can be used to create high density microfluidic devices with active components such as valves and pumps. Leveraging our previous work on optical formulation of inexpensive resins (RSC Adv., 2015, 5, 106621), we demonstrate valves with only 10% of the volume of our original 3D printed valves (Biomicrofluidics, 2015, 9, 016501), which were already the smallest that have been reported. Moreover, we show that incorporation of a thermal initiator in the resin formulation along with a post-print bake can dramatically improve the durability of 3D printed valves up to 1 million actuations. Using two valves and a valve-like displacement chamber (DC), we also create compact 3D printed pumps. With 5-phase actuation and a 15 ms phase interval, we obtain pump flow rates as high as 40 μL min−1. We also characterize maximum pump back pressure (i.e., maximum pressure the pump can work against), maximum flow rate (flow rate when there is zero back pressure), and flow rate as a function of the height of the pump outlet. We further demonstrate combining 5 valves and one DC to create a 3-to-2 multiplexer with integrated pump. In addition to serial multiplexing, we also show that the device can operate as a mixer. Importantly, we illustrate the rapid fabrication and test cycles that 3D printing makes possible by implementing a new multiplexer design to improve mixing, and fabricate and test it within one day.

Graphical abstract: High density 3D printed microfluidic valves, pumps, and multiplexers

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Publication details

The article was received on 28 Apr 2016, accepted on 24 May 2016 and first published on 24 May 2016


Article type: Paper
DOI: 10.1039/C6LC00565A
Citation: Lab Chip, 2016,16, 2450-2458
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    High density 3D printed microfluidic valves, pumps, and multiplexers

    H. Gong, A. T. Woolley and G. P. Nordin, Lab Chip, 2016, 16, 2450
    DOI: 10.1039/C6LC00565A

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