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Issue 12, 2016
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Modulating the microtubule–tau interactions in biomotility systems by altering the chemical environment

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Abstract

Obstacles in microtubule mediated neuronal transport can trigger dementia. We use bio-motility assays, that simulate the neuron chemistry in axonopathy, to screen chemicals, that retain the microtubule dynamics in healthy neuronal activity. Tau protein inhibits microtubule activity and leads to oligomerization. Iron(III) untangles, whereas mono-sodium-glutamate destabilizes the microtubule oligomer.

Graphical abstract: Modulating the microtubule–tau interactions in biomotility systems by altering the chemical environment

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Publication details

The article was received on 02 Sep 2016, accepted on 15 Oct 2016 and first published on 17 Oct 2016


Article type: Paper
DOI: 10.1039/C6IB00182C
Citation: Integr. Biol., 2016,8, 1296-1300
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    Modulating the microtubule–tau interactions in biomotility systems by altering the chemical environment

    S. Bhattacharyya, K. Kim, H. Nakazawa, M. Umetsu and W. Teizer, Integr. Biol., 2016, 8, 1296
    DOI: 10.1039/C6IB00182C

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