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Issue 24, 2016
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Base- and metal-free decarboxylative aldol reaction of β-ketoacids with glyoxylate hydrates and glyoxal monohydrates in water

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Abstract

An environmentally benign decarboxylative aldol reaction of β-ketoacids with glyoxylate and glyoxal monohydrates in water is reported. The reaction proceeds smoothly without any base and metal catalysts, affording the corresponding β-hydroxy ketones in high yields. A preliminary mechanism study of this aldol transformation suggests a stepwise process involving the nucleophilic addition of β-ketoacids to glyoxylate hydrates and glyoxal monohydrates followed by a subsequent decarboxylation reaction.

Graphical abstract: Base- and metal-free decarboxylative aldol reaction of β-ketoacids with glyoxylate hydrates and glyoxal monohydrates in water

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Publication details

The article was received on 28 Sep 2016, accepted on 06 Oct 2016 and first published on 06 Oct 2016


Article type: Paper
DOI: 10.1039/C6GC02705A
Citation: Green Chem., 2016,18, 6609-6617
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    Base- and metal-free decarboxylative aldol reaction of β-ketoacids with glyoxylate hydrates and glyoxal monohydrates in water

    N. Ren, J. Nie and J. Ma, Green Chem., 2016, 18, 6609
    DOI: 10.1039/C6GC02705A

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