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Issue 6, 2017
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Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

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Abstract

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.

Graphical abstract: Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

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Publication details

The article was received on 19 Sep 2016, accepted on 21 Oct 2016 and first published on 21 Oct 2016


Article type: Communication
DOI: 10.1039/C6GC02619B
Citation: Green Chem., 2017,19, 1420-1424
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    Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

    L. Huck, M. Berton, A. de la Hoz, A. Díaz-Ortiz and J. Alcázar, Green Chem., 2017, 19, 1420
    DOI: 10.1039/C6GC02619B

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