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Issue 24, 2016
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Q-SA√ESS: a methodology to help solvent selection for pharmaceutical manufacture at the early process development stage

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Abstract

A practicable, LCA based methodology has been developed to evaluate the sustainability implications of solvent selection during early process development for a batch manufacturing process for an API. Q-SA√ESS (Quick Sustainability Assessment via Experimental Solvent Selection) structures the early use of existing tools to carry out initial solvent selection on the basis of EHS factors and suitability for the desired chemistry. The life cycle of the solvent has been divided into three stages: solvent manufacture, use in the batch process and end of life/recycling. The application of the methodology is illustrated for a single example of chemistry which has been taken through from development lab to process evaluation towards pilot scale. This demonstrates how the methodology helps to select the solvent giving the lowest overall environmental impact.

Graphical abstract: Q-SA√ESS: a methodology to help solvent selection for pharmaceutical manufacture at the early process development stage

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Publication details

The article was received on 01 Sep 2016, accepted on 29 Sep 2016 and first published on 03 Oct 2016


Article type: Paper
DOI: 10.1039/C6GC02440H
Citation: Green Chem., 2016,18, 6564-6572
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    Q-SA√ESS: a methodology to help solvent selection for pharmaceutical manufacture at the early process development stage

    V. Isoni, L. L. Wong, H. H. Khoo, I. Halim and P. Sharratt, Green Chem., 2016, 18, 6564
    DOI: 10.1039/C6GC02440H

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