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Issue 22, 2016
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Catalyst-free direct C–H trifluoromethylation of arenes in water–acetonitrile

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Abstract

We describe a mild and practical strategy for the catalyst-free trifluoromethylation of arenes using the inexpensive solid sodium triflinate (Langlois’ reagent, NaSO2CF3) as a trifluoromethyl (CF3) source and solid sodium persulfate as an initiator. The reaction is environmentally friendly and proceeds at 30 °C in a water–acetonitrile mixture. This transformation can be easily scaled up to the gram level with excellent yield.

Graphical abstract: Catalyst-free direct C–H trifluoromethylation of arenes in water–acetonitrile

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Publication details

The article was received on 22 Jul 2016, accepted on 13 Sep 2016 and first published on 14 Sep 2016


Article type: Communication
DOI: 10.1039/C6GC02000C
Citation: Green Chem., 2016,18, 5967-5970
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    Catalyst-free direct C–H trifluoromethylation of arenes in water–acetonitrile

    D. Wang, G. Deng, S. Chen and H. Gong, Green Chem., 2016, 18, 5967
    DOI: 10.1039/C6GC02000C

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