Issue 15, 2016
From the journal:

Green Chemistry

Directed alkynylation of unactivated C(sp3)–H bonds with ethynylbenziodoxolones mediated by DTBP†

Zhi-Fei Cheng,a   Yi-Si Feng,*abc   Chun Rong,a   Tao Xu,a   Peng-Fei Wang,a   Jun Xu,a   Jian-Jun Daia  and  Hua-Jian Xu*abc  

* Corresponding authors

a School of Chemistry and Chemical Engineering, School of Biological and Medical Engineering, Hefei University of Technology, Hefei 230009, P. R. China

b Anhui Key Laboratory of Controllable Chemical Reaction and Material Chemical Engineering, Hefei 230009, P. R. China
E-mail: hjxu@hfut.edu.cn
Fax: (+86)-551-62904405

c Anhui Provincial Laboratory of Heterocyclic Chemistry, Maanshan 243110, China

Abstract

A general and efficient method for the direct alkynylation of unactivated C(sp3)–H bonds under metal-free conditions is described. The reaction performs smoothly under mild conditions and shows excellent functional-group tolerance. Initial mechanistic investigation indicates that the reaction may involve a radical pathway.

Graphical abstract: Directed alkynylation of unactivated C(sp3)–H bonds with ethynylbenziodoxolones mediated by DTBP

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Article information

DOI
https://doi.org/10.1039/C6GC01336H
Article type
Communication
Submitted
15 May 2016
Accepted
24 Jun 2016
First published
27 Jun 2016

Green Chem., 2016,18, 4185-4188

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Directed alkynylation of unactivated C(sp3)–H bonds with ethynylbenziodoxolones mediated by DTBP

Z. Cheng, Y. Feng, C. Rong, T. Xu, P. Wang, J. Xu, J. Dai and H. Xu, Green Chem., 2016, 18, 4185 DOI: 10.1039/C6GC01336H

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