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Issue 9, 2016
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Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

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Abstract

A continuous-flow approach towards the selective nanopalladium-catalyzed hydrogenation of the olefinic bond in various Michael acceptors, which could lead to a greener and more sustainable process, has been developed. The nanopalladium is supported on aminofunctionalized mesocellular foam. Both aromatic and aliphatic substrates, covering a variation of functional groups such as acids, aldehydes, esters, ketones, and nitriles were selectively hydrogenated in high to excellent yields using two different flow-devices (H-Cube® and Vapourtec). The catalyst was able to hydrogenate cinnamaldehyde continuously for 24 h (in total hydrogenating 19 g cinnanmaldehyde using 70 mg of catalyst in the H-cube®) without showing any significant decrease in activity or selectivity. Furthermore, the metal leaching of the catalyst was found to be very low (ppb amounts) in the two flow devices.

Graphical abstract: Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

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Publication details

The article was received on 07 Dec 2015, accepted on 24 Feb 2016 and first published on 26 Feb 2016


Article type: Communication
DOI: 10.1039/C5GC02920A
Citation: Green Chem., 2016,18, 2632-2637
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    Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

    A. Nagendiran, H. Sörensen, M. J. Johansson, C. Tai and Jan-E. Bäckvall, Green Chem., 2016, 18, 2632
    DOI: 10.1039/C5GC02920A

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