Metal-free oxidative carbonylation on enaminone CC bond for the cascade synthesis of benzothiazole-containing vicinal diketones

Abstract

The cascade reactions between enaminones and o-aminothiophenols have been implemented to provide unprecedented vicinal diketones containing benzothiazole structures. The construction of the products has been realized under metal-free conditions via carbonylation on the CC double bond of the enaminone. The tunable synthesis of 2-aroylbenzothiazoles has been achieved by using identical starting materials under modified reaction conditions.