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Issue 11, 2016
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Yerba mate (Ilex paraguariensis) inhibits lymphocyte activation in vitro

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Abstract

Yerba mate (YM) has been shown to have anti-inflammatory properties in several studies. However, this effect has been found mainly in obesity-related inflammation. The aim of this work was to study the effect of YM on cultured peripheral blood mononuclear cells to see whether it has anti-inflammatory properties. We stimulated peripheral blood mononuclear cells in vitro with phytohemagglutinin (PHA) in the presence of yerba mate and determined their activation by measuring the expression of CD25 by flow cytometry. We observed that YM treatment produced a dose-dependent reduction in PBMC activation (CD25 positive cells) when they were stimulated with PHA. This effect was also observed in T cells’ (CD3 positive) subpopulation. Microarray analysis revealed the differential expression of 128 genes in YM-treated cells. According to a protein–protein interaction database, these genes were highly connected and they are involved in the inflammatory response. In summary, it was demonstrated that YM produces a reduction in the amount of activated cells under the stimulation of PHA. Therefore, it might be used in diseases with an inflammatory component.

Graphical abstract: Yerba mate (Ilex paraguariensis) inhibits lymphocyte activation in vitro

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Publication details

The article was received on 15 Jul 2016, accepted on 16 Sep 2016 and first published on 19 Sep 2016


Article type: Paper
DOI: 10.1039/C6FO01061J
Citation: Food Funct., 2016,7, 4556-4563
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    Yerba mate (Ilex paraguariensis) inhibits lymphocyte activation in vitro

    M. Muñoz-Culla, M. Sáenz-Cuesta, M. J. Guereca-Barandiaran, M. L. Ribeiro and D. Otaegui, Food Funct., 2016, 7, 4556
    DOI: 10.1039/C6FO01061J

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