Issue 6, 2016

Porcine myofibrillar proteins as potential precursors of bioactive peptides – an in silico study

Abstract

Selected porcine myofibrillar proteins have been assessed as potential precursors of bioactive peptides based on in silico analysis. The potential of protein sequences for releasing peptides was evaluated by determining the profile of their potential biological activity and the frequency of occurrence of fragments with a given activity using the BIOPEP database. Digestive enzymes: pepsin, trypsin and chymotrypsin have been used for the in silico proteolysis with the use of the “Enzyme(s) action” tool in BIOPEP. After simulated gastrointestinal digestion the tested sequences of pig myofibrillar proteins are a potential source of a total of 399 peptides with activities such as enzyme inhibition, antioxidative, hypotensive, stimulating or regulating various body functions and antiamnestic activities. Within the intact proteins and after simulated gastrointestinal digestion, dipeptidyl peptidase IV inhibitory peptide sequences were the most frequently observed. The results indicate that pork myofibrillar proteins are a promising source of peptides with biological activity.

Graphical abstract: Porcine myofibrillar proteins as potential precursors of bioactive peptides – an in silico study

Article information

Article type
Paper
Submitted
30 Dec 2015
Accepted
20 May 2016
First published
24 May 2016

Food Funct., 2016,7, 2878-2885

Porcine myofibrillar proteins as potential precursors of bioactive peptides – an in silico study

P. Kęska and J. Stadnik, Food Funct., 2016, 7, 2878 DOI: 10.1039/C5FO01631B

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