Jump to main content
Jump to site search

Issue 1, 2016
Previous Article Next Article

Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent

Author affiliations

Abstract

Grape-seed proanthocyanidins’ role as stimulators of active GLP-1 in rats suggests that they could be effective as satiating agents. Wistar rats were used to study the effects of proanthocyanidins on food intake with different doses, administration times and proanthocyanidin extract compositions. A dose of 423 mg of phenolics per kg body weight (BW) of grape-seed proanthocyanidin extract (GSPE) was necessary to decrease the 12-hour cumulative food intake by 18.7 ± 3.4%. Proanthocyanidins were effective when delivered directly into the gastrointestinal tract one hour before, or simultaneously at the start of the feeding period. Proanthocyanidins without galloyl forms, such as those from cocoa extract, were not as effective as grape-seed derived forms. GSPE increased the portal levels of active GLP-1 and total ghrelin and decreased the CCK levels, simultaneously with a decrease in gastric emptying. In conclusion, grape-seed proanthocyanidins could be useful as a satiating agent under the conditions defined in this study.

Graphical abstract: Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Jul 2015, accepted on 14 Oct 2015 and first published on 30 Oct 2015


Article type: Paper
DOI: 10.1039/C5FO00892A
Citation: Food Funct., 2016,7, 483-490
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent

    J. Serrano, À. Casanova-Martí, K. Gil-Cardoso, M. T. Blay, X. Terra, M. Pinent and A. Ardévol, Food Funct., 2016, 7, 483
    DOI: 10.1039/C5FO00892A

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements