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Issue 1, 2016
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Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent

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Abstract

Grape-seed proanthocyanidins’ role as stimulators of active GLP-1 in rats suggests that they could be effective as satiating agents. Wistar rats were used to study the effects of proanthocyanidins on food intake with different doses, administration times and proanthocyanidin extract compositions. A dose of 423 mg of phenolics per kg body weight (BW) of grape-seed proanthocyanidin extract (GSPE) was necessary to decrease the 12-hour cumulative food intake by 18.7 ± 3.4%. Proanthocyanidins were effective when delivered directly into the gastrointestinal tract one hour before, or simultaneously at the start of the feeding period. Proanthocyanidins without galloyl forms, such as those from cocoa extract, were not as effective as grape-seed derived forms. GSPE increased the portal levels of active GLP-1 and total ghrelin and decreased the CCK levels, simultaneously with a decrease in gastric emptying. In conclusion, grape-seed proanthocyanidins could be useful as a satiating agent under the conditions defined in this study.

Graphical abstract: Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent

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Publication details

The article was received on 21 Jul 2015, accepted on 14 Oct 2015 and first published on 30 Oct 2015


Article type: Paper
DOI: 10.1039/C5FO00892A
Citation: Food Funct., 2016,7, 483-490
  • Open access: Creative Commons BY-NC license
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    Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent

    J. Serrano, À. Casanova-Martí, K. Gil-Cardoso, M. T. Blay, X. Terra, M. Pinent and A. Ardévol, Food Funct., 2016, 7, 483
    DOI: 10.1039/C5FO00892A

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